Node: The most passive aggressive language I've had the displeasure of programming in.

Reference an undefined variable in a module? Prepare to waste your time hunting for it, because the runtime won't tell you about it until you reference a property or method on the quietly undefined module object.

Think you know how promises work? As a hiring manager, I've found that less than 5% of otherwise well-experienced devs are out of the Dunning Kruger danger zone.

Async causes edge cases and extra dev effort that add to the effort required to make a quality product.

Got a bug in one of your modules? Prepare yourself for some downtime because a single misplaced parentheses can take out the entire Node process, killing unrelated pages and even static file hosting.

All this makes for a programming experience that demands much higher cognitive load, creates more categories of bugs, and leads to code bloat/smell much more quickly than other commonly substituted languages.

From a business perspective, the money you save on scaling (assuming your app is more compute efficient under Node) is wasted on salaries and opportunity costs stemming from longer dev time, more QA, and more frequent outages.

IMO, Node is an awesome experiment, a fun language, a great tool for specific use cases, and a terrible fucking choice for an entire website.